5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase

US7728003B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Mark R. Player · Phoenixville, US
• Hui Huang · Blue Bell, US
• Hu Huaping · Pennington, US
• Renee Louise Desjarlais · Saint Davids, US

Key dates

• Filing date: Sep 12, 2006
• Grant date: Jun 1, 2010
• Expiry date: Apr 2, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I:or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, n, Z, and R102 are described in the specification.