Method of modulating stress-activated protein kinase system
US7728013B2 · kind B2 · utility
35Cited by
5References
19Claims
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Key dates
| Filing date | May 9, 2006 |
| Grant date | Jun 1, 2010 |
| Priority date | — |
| Expiry date | Dec 21, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the at least one p38 MAPK by the compound. Also disclosed are derivatives of pirfenidone. These derivatives can modulate a stress activated protein kinase (SAPK) system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.