Crystal structure of hepatocyte growth factor activator complexed with Kunitz domain inhibitor
US7741096B2 · kind B2 · utility
11Cited by
6References
14Claims
0Family size
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Key dates
| Filing date | Dec 9, 2005 |
| Grant date | Jun 22, 2010 |
| Priority date | — |
| Expiry date | May 24, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides crystals of and structural coordinates of Hepatocyte growth factor activator with and without bound pseudo-substrate or inhibitor. In a specific embodiment, a crystal structure of activated HGFA complexed with a Kunitz domain inhibitor is provided. The crystals and crystal structures are useful, for example, in the design and synthesis of inhibitors of HGFA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.