Peptides for activation and inhibition of δPKC

US7745388B2 · kind B2 · utility

Assignees

• NATIONAL INSTITUTES OF HEALTH (NIH) · US
• The United States of America, as represented by the Department of Health and Human Services · US
• The United States of America as represented by NIH Division of Extramural Inventions and Technology Resources (DEITR) · US

Inventors

• Daria Mochly-Rosen · Menlo Park, US
• Leon E. Chen · Cupertino, US

Key dates

• Filing date: May 12, 2004
• Grant date: Jun 29, 2010
• Expiry date: May 12, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides able to inhibit or activate the translocation or function of δPKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for δPKC-selective agonists and antagonists.