Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
US7749984B2 · kind B2 · utility
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16References
5Claims
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Key dates
| Filing date | Apr 9, 2004 |
| Grant date | Jul 6, 2010 |
| Priority date | — |
| Expiry date | Apr 16, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.