Chloral-free DCA in oligonucleotide synthesis
US7759480B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jan 29, 2007 |
| Grant date | Jul 20, 2010 |
| Priority date | — |
| Expiry date | May 4, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.