Antidiabetic bicyclic compounds

US7759493B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Min Ge · Nanjing, CN
• Lihu Yang · Edison, US
• Changyou Zhou · Princeton, US
• Songnian Lin · Sparta, US
• Haifeng Tang · South San Francisco, US
• Eric Dean Cline · Princeton, US
• Sunita Malkani · Lincoln Park, US

Key dates

• Filing date: Jan 30, 2006
• Grant date: Jul 20, 2010
• Expiry date: Aug 30, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.