Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC)

US7776883B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Roberto Di Santo · Roma, IT
• Yves Pommier · Bethesda, US
• Christophe Marchand · Gaithersburg, US
• Marino Artico · Roma, IT
• Roberta Costi · Roma, IT

Key dates

• Filing date: Mar 9, 2005
• Grant date: Aug 17, 2010
• Expiry date: Nov 25, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Novel quinoline inhibitors of retroviral integrase, particularly HIV-1 integrase. The quinoline inhibitors are oxoquinolines that can be used for preventing or treating AIDS or HIV infection in a subject.