CETP inhibitors

US7781426B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Amjad Ali · Freehold, US
• Zhijian Lu · Clinton, US
• Peter J. Sinclair · Highland Park, US
• Gayle E. Taylor · Jersey City, US
• Christopher F. Thompson · Arlington, US
• Cameron Smith · Lawrenceville, US
• Adrian A. Dowst · Hoboken, US
• Yi-Heng Chen · Whippany, US

Key dates

• Filing date: Dec 29, 2006
• Grant date: Aug 24, 2010
• Expiry date: Jan 5, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B or R2 is a phenyl group which has an ortho amine or aminomethyl substituent which is further substituted, and the other of B or R2 is also a cyclic group.