Synthesis of indenoisoquinoliniums and methods of use

US7781445B2 · kind B2 · utility

Assignees

• Purdue Research Foundation · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Mark S. Cushman · West Lafayette, US
• Alexandra S. Ioanoviciu · San Francisco, US
• Yves G. Pommier · Bethesda, US

Key dates

• Filing date: Mar 15, 2005
• Grant date: Aug 24, 2010
• Expiry date: Aug 1, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted indenoisoquinolinium compounds, and pharmaceutical formulations of substituted indenoisoquinolinium compounds are described. Also described are processes for preparing substituted indenoisoquinolinium compounds. Also described are methods for treating cancer in mammals using the described substituted indenoisoquinolinium compounds or pharmaceutical formulations thereof.