Patent · US Active

2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)

US7786116B2 · kind B2 · utility

1Cited by

20References

11Claims

0Family size

Assignee

Janssen Pharmaceutica NA · BE

Inventors

Ellen W. Baxter · Glenside, US
Christopher J. Creighton · San Diego, US
Chih Yung Ho · Lansdale, US
Yifang Huang · Cheltenham, US
Tianbao Lu · Collegeville, US
Chi Luo · Lansdale, US
Allen B. Reitz · Lansdale, US
Charles H. Reynolds · Austin, US
Tina Morgan Ross · Limerick, US
Ellen Sieber-McMaster · Langhorne, US

Key dates

Filing date	Jan 29, 2009
Grant date	Aug 31, 2010
Priority date	—
Expiry date	Jan 29, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of β-secretase, also known as β-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.