Phthalazine derivatives as parp inhibitors

US7803795B2 · kind B2 · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Laurence Anne Mevellec · Louviers, FR
• Ludo Edmond Josephine Kennis · Lier, BE
• Josephus Carolus Mertens · Oud-Turnhout, BE
• Jacobus Alphonsus Josephus Van Dun · Kasterlee, BE
• Maria Victorina Francisca Somers · Vosselaar, BE
• Walter Boudewijn Leopold Wouters · Kapellen, BE

Key dates

• Filing date: Jun 28, 2005
• Grant date: Sep 28, 2010
• Expiry date: Dec 30, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2 L1, L2, X, Y, Q and Z have defined meanings.