Systems and methods for high-throughput radiation biodosimetry

US7822249B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Guy Garty · Dobbs Ferry, US
• David Jonathan Brenner · New York, US
• Gerhard Randers-Pehrson · Ossining, US
• Y. Lawrence Yao · New York, US
• Nabil Simaan · Nashville, US
• Alessio Salerno · Montréal, CA
• Anubha Bhatla · Secaucus, US
• Jian Zhang · Brookline, US
• Oleksandra V. Lyulko · New York, US
• Aparajita Dutta · Waltham, US

Key dates

• Filing date: Aug 24, 2007
• Grant date: Oct 26, 2010
• Expiry date: Feb 2, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/…