Method for using antibodies for inhibiting blood coagulation
US7824677B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 10, 2008 |
| Grant date | Nov 2, 2010 |
| Priority date | — |
| Expiry date | Oct 28, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes methods of inhibiting blood coagulation using antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Methods of the invention can effectively inhibit blood coagulation in vivo. Antibodies used in the methods of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies used in the methods of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.