Patent · US Active

(Arylamidoaryl)squaramide compounds

US7829717B2 · kind B2 · utility

0Cited by

0References

14Claims

0Family size

Assignee

OSI Pharmaceuticals, LLC · US

Inventors

Arlindo L. Castelhano · Haverstraw, US
Andrew P. Crew · Farmingdale, US
Hanqing Dong · Madison, US
An-Hu Li · New York, US
Li Qiu · Farmingdale, US
Alun John Smith · Birmingham, GB
Lawrence Tardibono · The Bronx, US
Tao Zhang · Waltham, US

Key dates

Filing date	Sep 15, 2005
Grant date	Nov 9, 2010
Priority date	—
Expiry date	Dec 12, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compounds represented by Formula (I):or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.