Conjugates and compositions for cellular delivery

US7833992B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Chandra Vargeese · Schwenksville, US
• Peter Haeberli · Berthoud, US
• Weimin Wang · Hangzhou City, CN
• Tongqian Chen · Longmont, US

Key dates

• Filing date: Apr 30, 2003
• Grant date: Nov 16, 2010
• Expiry date: May 18, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.