Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto

US7834005B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• STARKS ASSOCIATES INC. · US
• Midwest Research Institute, Inc. · US
• SPIROGEN LIMITED · GB

Inventors

• Paul S. Liu · Bethesda, US
• B. Rao Vishnuvajjala · Rockville, US
• Kenneth M. Snader · Germantown, US
• David E. Thurston · Fareham, GB
• Philip Wilson Howard · London, GB
• Luke Y. Hsiao · San Diego, US
• Gregory Turner · Independence, US

Key dates

• Filing date: Feb 13, 2009
• Grant date: Nov 16, 2010
• Expiry date: Feb 13, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula Iwherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.