Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
US7838290B2 · kind B2 · utility
3Cited by
2References
3Claims
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Key dates
| Filing date | Apr 28, 2004 |
| Grant date | Nov 23, 2010 |
| Priority date | — |
| Expiry date | Aug 23, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/124
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin− HSCs) contain endothelial progenitor cells (EPCs) capable of rescuing retinal blood vessels and neuronal networks in the eye. Preferably at least about 20% of the cells in the isolated Lin− HSCs express the cell surface antigen CD31 and not more than about 1 percent of the cells express Tie-2. The isolated Lin− HSC populations are useful for treatment of ocular vascular diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.