Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same

US7846928B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Ingo Hartung · Berlin, DE
• Stuart Ince · Berlin, DE
• Georg Kettschau · Berlin, DE
• Karl-Heinz Thierauch · Berlin, DE
• Hans Briem · Bremen, DE
• Ulf Boemer · Hohen Neuendorf, DE

Key dates

• Filing date: Jun 12, 2007
• Grant date: Dec 7, 2010
• Expiry date: May 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted pyrazolopyridines according to the general formula (I):in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted pyrazolopyridine compounds, to methods of preparing said substituted pyrazolopyridines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.