Patent · US Active

2-Azapurine compounds and their use

US7847075B2 · kind B2 · utility

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0References

4Claims

0Family size

Assignee

Roche Molecular Systems, Inc. · US

Inventors

Frank Seela · Osnabrück, DE
Helmut Rosemeyer · Osnabrück, DE
Enno Schweinberger · Bodenfelde, DE
Dieter Heindl · Munich, DE
Frank Bergmann · Iffeldorf, DE

Key dates

Filing date	Aug 13, 2009
Grant date	Dec 7, 2010
Priority date	—
Expiry date	Aug 13, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6813
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.