D3 and 5-HT2A receptor modulators
US7858630B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 16, 2009 |
| Grant date | Dec 28, 2010 |
| Priority date | — |
| Expiry date | Sep 16, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of the general formula (I)wherein X, n and R1 are as described herein, as well as pharmaceutically acceptable salts and esters thereof, methods for their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, useful in the treatment and/or the prevention of cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and psychoses comprising paranoia and delusions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.