Methods of treatment and uses for CaMKII and its interaction with HDACs and calpain
US7863414B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 17, 2006 |
| Grant date | Jan 4, 2011 |
| Priority date | — |
| Expiry date | Oct 5, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.