Compositions useful as inhibitors of GSK-3

US7872129B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Cornelia Forster · Bensalem, US
• Larry C. Park · Waltham, US
• Marion W. Wannamaker · Sharonville, US
• Yung-Mae M. Yao · Newton, US

Key dates

• Filing date: Dec 18, 2008
• Grant date: Jan 18, 2011
• Expiry date: Dec 18, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I:or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.