Patent · US Active

Dual-acting imidazole antihypertensive agents

US7879896B2 · kind B2 · utility

40Cited by

23References

30Claims

0Family size

Assignee

Theravance, Inc. · US

Inventors

Paul Allegretti · Fort Collins, US
Seok-Ki Choi · Ann Arbor, US
Roland Gendron · San Francisco, US
Paul R. Fatheree · San Francisco, US
Keith Jendza · Boston, US
Robert Murray McKinnell · Millbrae, US
Darren McMurtrie · Daly City, US
Brooke Olson · Williamstown, US

Key dates

Filing date	Apr 23, 2008
Grant date	Feb 1, 2011
Priority date	—
Expiry date	Feb 12, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is directed to compounds having the formula:wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.