Angiotensin II receptor antagonists

US7880014B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• NICOX S.A. · FR

Inventors

• Iyassu Sebhat · Jersey City, US
• Michael Man-Chu Lo · Rahway, US
• Ravi Nargund · East Brunswick Township, US
• Amjad Ali · Freehold, US
• Chris Franklin · Keasbey, US
• Nicoletta Almirante · Milano, IT
• Laura Storoni · Cesano Maderno, IT
• Silvia Stefanini · San Donato Milanese, IT

Key dates

• Filing date: Dec 11, 2007
• Grant date: Feb 1, 2011
• Expiry date: Jan 6, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound having the structurewherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.