Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases

US7888116B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Josephine Egan · Baltimore, US
• Maire Doyle · Baltimore, US

Key dates

• Filing date: Jul 22, 2005
• Grant date: Feb 15, 2011
• Expiry date: Apr 13, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/042
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.