Tetrahydrocarbazoles and derivatives

US7906546B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Henrietta Dehmlow · Weil am Rhein, DE
• Bernd Kuhn · Sursee, CH
• Raffaello Masciadri · Basel, CH
• Narendra Panday · Basel, CH
• Hasane Ratni · Habsheim, FR
• Matthew Wright · Basel, CH

Key dates

• Filing date: May 6, 2010
• Grant date: Mar 15, 2011
• Expiry date: May 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formula (I)wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXRβ agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.