Monoclonal antibodies against orthopoxviruses

US7914788B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Zhaochun Chen · Potomac, US
• Patricia Earl · Bethesda, US
• Bernard Moss · Bethesda, US
• Suzanne U. Emerson · Rockville, US
• Robert H. Purcell · Boyds, US

Key dates

• Filing date: Jun 19, 2008
• Grant date: Mar 29, 2011
• Expiry date: Jun 19, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.