Patent · US Active

Engineered cleavage half-domains

US7914796B2 · kind B2 · utility

128Cited by

33References

19Claims

0Family size

Assignee

Sangamo Biosciences, Inc. · US

Inventors

Jeffrey C. Miller · Pleasanton, US
Michael C. Holmes · Richmond, US
Gregory J. Cost · Berkeley, US

Key dates

Filing date	Jul 2, 2008
Grant date	Mar 29, 2011
Priority date	—
Expiry date	Jan 1, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/22
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising these polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.