Inventor · Richmond, CA, US

Michael C. Holmes

65Patents
15h-index
49Co-inventors
84Inventor score

Filing activity: May 13, 1999 → Dec 18, 2020

Most-cited inventions

PatentTitleAreaCited byStatus
US7888121B2 Methods and compositions for targeted cleavage and recombination Chemistry; Metallurgy 170 Expired
US8956828B2 Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Chemistry; Metallurgy 128 Active
US7914796B2 Engineered cleavage half-domains Chemistry; Metallurgy 128 Active
US7951925B2 Methods and compositions for gene inactivation Chemistry; Metallurgy 100 Active
US9597357B2 T cell modifying compounds and uses thereof Emerging Cross-Sectional Technologies 93 Active
US8409861B2 Targeted deletion of cellular DNA sequences Chemistry; Metallurgy 89 Active
US8945868B2 Methods and compositions for modification of a HLA locus Chemistry; Metallurgy 76 Active
US8563314B2 Methods and compositions for modulating PD1 Emerging Cross-Sectional Technologies 53 Active
US9045763B2 Linear donor constructs for targeted integration Chemistry; Metallurgy 50 Active
US9616090B2 Gene correction of SCID-related genes in hematopoietic stem and progenitor cells Human Necessities 42 Active
US9937207B2 Targeted disruption of T cell receptor genes using talens Chemistry; Metallurgy 35 Active
US8771985B2 Genome editing of a Rosa locus using zinc-finger nucleases Chemistry; Metallurgy 34 Active
US9434776B2 Methods and compositions for gene inactivation Chemistry; Metallurgy 22 Active
US9566352B2 Methods and compositions for inhibiting viral entry into cells Chemistry; Metallurgy 21 Active
US9222105B2 Methods and compositions for modification of the HPRT locus Chemistry; Metallurgy 15 Active
US9957526B2 Delivery methods and compositions for nuclease-mediated genome engineering Chemistry; Metallurgy 11 Active
US9782437B2 Methods and compositions for targeted cleavage and recombination Chemistry; Metallurgy 9 Active
US8936936B2 Methods and compositions for targeted integration Chemistry; Metallurgy 8 Active
US9175280B2 Methods and compositions for treating hemophilia B Human Necessities 8 Active
US9629930B2 Methods and compositions for treating hemophilia B Human Necessities 8 Active
US9161995B2 Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene Chemistry; Metallurgy 7 Active
US8871905B2 Modification of CXCR4 using engineered zinc finger proteins Chemistry; Metallurgy 7 Active
US10046028B2 Methods and compositions for modulating PD1 Emerging Cross-Sectional Technologies 6 Active
US8895264B2 Methods and compositions for modification of the HPRT locus Chemistry; Metallurgy 6 Active
US10072062B2 Methods and compositions for modification of a HLA locus Chemistry; Metallurgy 6 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.