1,3-oxazolidin-2-one derivatives useful as CETP inhibitors

US7915271B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Amjad Ali · Freehold, US
• Zhijian Lu · Clinton, US
• Peter J. Sinclair · Highland Park, US
• Yi-Heng Chen · Whippany, US
• Cameron Smith · Lawrenceville, US
• Hong Li · Edison, US

Key dates

• Filing date: Dec 29, 2006
• Grant date: Mar 29, 2011
• Expiry date: May 7, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.