Modulators for amyloid beta

US7923450B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Karlheinz Baumann · Weil am Rhein, DE
• Alexander Flohr · Basel, CH
• Erwin Goetschi · Reinach, CH
• Helmut Jacobsen · Schopfheim, DE
• Synese Jolidon · Blauen, CH
• Thomas Luebbers · Soest, DE

Key dates

• Filing date: Jan 5, 2009
• Grant date: Apr 12, 2011
• Expiry date: Jan 5, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formulawherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.