Cell lines and host nucleic acid sequences related to infectious disease

US7927793B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• VANDERBILT UNIVERSITY · US

Inventors

• Thomas Hodge · Roswell, US
• Natalie McDonald · Atlanta, US
• Michael W. Shaw · Decatur, US
• Donald Rubin · Nashville, US
• Anthony Sanchez · Lilburn, US

Key dates

• Filing date: Nov 18, 2003
• Grant date: Apr 19, 2011
• Expiry date: May 17, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.