Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates

US7928079B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Joseph A. Hrabie · Frederick, US
• Larry K. Keefer · Bethesda, US

Key dates

• Filing date: Oct 16, 2006
• Grant date: Apr 19, 2011
• Expiry date: Sep 15, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P27/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds capable of releasing nitric oxide wherein the compounds comprise a saccharide and at least one nitric oxide-releasing diazeniumdiolate [N2O2] functional group, which is bonded directly to a carbon atom of the saccharide, and methods for preparing the same. The invention further comprises the treatment of biological disorders treatable by the administration of nitric oxide.