Crystal structure of CRIg and C3b:CRIg complex
US7930109B2 · kind B2 · utility
1Cited by
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15Claims
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Key dates
| Filing date | Dec 14, 2009 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Dec 14, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention concerns determination of the crystal structure of the macrophage specific receptor, CRIg (earlier referred to as STIgMA), and its complex with the C3b and C3c subunits of complement C3 (C3b:CRIg and C3c:CRIg complexes). The invention further concerns the use of the crystal structure of CRIg or the C3b:CRIg complex to screen for and identify molecules structurally and/or functionally related to CRIg, including CRIg agonists and antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.