Peptide inhibitors of hepatitis C virus replication

US7932277B2 · kind B2 · utility

Assignees

• INTERMUNE, INC. · US
• Array BioPharma, Inc. · US

Inventors

• Scott D. Seiwert · Pacifica, US
• Steven W. Andrews · Longmont, US
• Leonid Beigelman · San Mateo, US
• Lawrence M. Blatt · San Francisco, US
• Brad O. Buckman · Oakland, US
• Kevin Ronald Condroski · Lafayette, US
• Yutong Jiang · Boulder, US
• Robert J. Kaus · Longmont, US
• April L. Kennedy · Denver, US
• Timothy Kercher · Longmont, US
• Michael Lyon · Boulder, US
• Bin Wang · Beijing, CN

Key dates

• Filing date: May 9, 2008
• Grant date: Apr 26, 2011
• Expiry date: Oct 18, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.