Use of CPG oligodeoxynucleotides to induce angiogenesis

US7935351B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• University of Tennessee Research Foundation · US

Inventors

• Dennis Klinman · Potomac, US
• Mei ZHENG · Augusta, US
• Barry T. Rouse · Knoxville, US

Key dates

• Filing date: Aug 15, 2007
• Grant date: May 3, 2011
• Expiry date: Sep 14, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides a method of inducing production of vascular endothelial growth factor by a cell. The method includes contacting the cell with a CpG oligonucleotide, thereby inducing the production of vascular endothelial growth factor by the cell. The disclosure further provides a method inducing neovascularization in a tissue. This method includes comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, thereby inducing neovascularization in the area of the tissue.