Patent · US Active

Methods and compositions for gene inactivation

US7951925B2 · kind B2 · utility

100Cited by

28References

22Claims

0Family size

Assignee

Sangamo Biosciences, Inc. · US

Inventors

Dale Ando · Richmond, US
Michael C. Holmes · Richmond, US
Gary K. Lee · San Leandro, US

Key dates

Filing date	May 23, 2007
Grant date	May 31, 2011
Priority date	—
Expiry date	Apr 9, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2710/10345
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.