Modulators of ATP-binding cassette transporters

US7956052B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Sara S. Hadida Ruah · Village of La Jolla, US
• Matthew Hamilton · Hackettstown, US
• Mark Miller · San Diego, US
• Peter D.J. Grootenhuis · San Diego, US
• Brian Bear · Oceanside, US
• Jason McCartney · Encinitas, US
• Jinglan Zhou · San Diego, US
• Fredrick Van Goor · San Diego, US

Key dates

• Filing date: Dec 4, 2009
• Grant date: Jun 7, 2011
• Expiry date: Dec 4, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.