Method for rapid generation of mature dendritic cells

US7959934B2 · kind B2 · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Dennis Klinman · Potomac, US
• Mayda Gursel · Ankara, TR
• Daniela Verthelyi · Potomac, US

Key dates

• Filing date: Mar 28, 2008
• Grant date: Jun 14, 2011
• Expiry date: Jul 24, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/056
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel methods of rapidly generating dendrtic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one specific, non-limiting example, the method includes contacting the dendritic cell precursor or the mature dendritic cell with an antigen. The methods are of use both in vitro and in vivo.