Method of designing siRNAs for gene silencing
US7962316B2 · kind B2 · utility
1Cited by
1References
37Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2004 |
| Grant date | Jun 14, 2011 |
| Priority date | — |
| Expiry date | Aug 28, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.