Imidazole derivatives

US7964620B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Bernd Buettelmann · Palo Alto, US
• Simona M. Ceccarelli · Basel, CH
• Georg Jaeschke · Basel, CH
• Sabine Kolczewski · Lörrach, DE
• Richard Hugh Philip Porter · Sursee, CH
• Eric Vieira · Frenkendorf, CH

Key dates

• Filing date: Sep 17, 2008
• Grant date: Jun 21, 2011
• Expiry date: Jun 10, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to imidazole derivatives of formula Iwherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the imidazole derivatives of formula I, a process for preparing a compound of formula I, and a method of treating or preventing acute and/or chronic neurological disorder comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said pharmaceutical composition. These disorders include Alzheimer's disease. These disorders also include mild cognitive impairment.