2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US7973013B2 · kind B2 · utility
107Cited by
0References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 20, 2010 |
| Grant date | Jul 5, 2011 |
| Priority date | — |
| Expiry date | Sep 20, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.