c-MET modulators and method of use

US7977345B2 · kind B2 · utility

Assignee

• Exelixis, Inc. · US

Inventors

• Lynne Canne Bannen · Lucerne, US
• Diva Sze-Ming Chan · San Francisco, US
• Lisa Esther Dalrymple · Seattle, US
• Vasu Jammalamadaka · Irvine, US
• Richard George Khoury · Redwood City, US
• James William Leahy · San Leandro, US
• Morrisson B. Mac · San Francisco, US
• Grace Mann · Brisbane, US
• Larry W. Mann · Redwood City, US
• John M. Nuss · Danville, US
• Jason Jevious Parks · Sacramento, US
• Yong Wang · South San Francisco, US
• Wie Xu · Danville, US

Key dates

• Filing date: Jul 1, 2005
• Grant date: Jul 12, 2011
• Expiry date: Jul 1, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound for modulating kinase activity according to Formula I,or a pharmaceutically acceptable salt thereof, Wherein J1, J2, J3, R2, J4, Z, Ar and R3 are as defined in the specification, compositions thereof, and methods of use thereof.