Synthetic antibody phage libraries
US7985840B2 · kind B2 · utility
41Cited by
40References
49Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 9, 2004 |
| Grant date | Jul 26, 2011 |
| Priority date | — |
| Expiry date | Jun 2, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/622
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides comprising variant amino acids in CDRs of antibody variable domains. These polypeptides provide a source of great sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags, and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.