Human monoclonal antibodies against Hendra and Nipah viruses

US7988971B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. · US

Inventors

• Dimiter S. Dimitrov · Frederick, US
• Zhu Zhongyu · Frederick, US
• Christopher C. Broder · Silver Spring, US

Key dates

• Filing date: Nov 4, 2005
• Grant date: Aug 2, 2011
• Expiry date: Feb 25, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.