Patent · US Active

Microorganisms and processes for enhanced production of pantothenate

US7989187B2 · kind B2 · utility

1Cited by

7References

34Claims

0Family size

Assignee

BASF SE

Inventors

Rogers Yocum · Lexington, US
Thomas A. Patterson · Attleboro, US
Janice G. Pero · Lexington, US
Theron Hermann · Arlington, US

Key dates

Filing date	Jul 3, 2003
Grant date	Aug 2, 2011
Priority date	—
Expiry date	Jun 19, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P13/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.