4,5-dihydro-oxazol-2-yl amine derivatives

US7989449B2 · kind B2 · utility

Assignees

• Hoffmann-La Roche Inc. · US
• SIENA BIOTECH S.P.A. · IT

Inventors

• Matteo Andreini · Siena, IT
• Emanuele Gabellieri · Lausanne, CH
• Wolfgang Guba · Memmingen, DE
• Guido Marconi · Siena, IT
• Robert Narquizian · La Valette-du-Var, FR
• Eoin Power · Siena, IT
• Massimiliano Travagli · Siena, IT
• Thomas Woltering · Freiburg (Elbe), DE
• Wolfgang Wostl · Weil am Rhein, DE

Key dates

• Filing date: Feb 12, 2009
• Grant date: Aug 2, 2011
• Expiry date: Jan 16, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a compounds of formula Iwherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceutically active acid addition salts thereof. Compounds of the invention have Asp2 (β-secretase, BACE 1 or Memapsin-2) inhibitory activity and are useful for the treatment of diseases characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.