2-aminoquinolines

US7989628B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Sabine Kolczewski · Lörrach, DE
• Claus Riemer · Glückstadt, DE
• Olivier Roche · Folgensbourg, FR
• Lucinda Steward · Basel, CH
• Juergen Wichmann · Basel, CH
• Thomas Woltering · Freiburg (Elbe), DE

Key dates

• Filing date: Feb 27, 2009
• Grant date: Aug 2, 2011
• Expiry date: May 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is concerned with 2-aminoquinoline derivatives of formula Iwherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5-HT5A receptor antagonists and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.