Unnatural reactive amino acid genetic code additions
US7993872B2 · kind B2 · utility
7Cited by
9References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 16, 2004 |
| Grant date | Aug 9, 2011 |
| Priority date | — |
| Expiry date | Aug 10, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.